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ISIS PHARMA
ISIS PHARMA Unitone 4 Advance Pigmentation and Spot Lightening CreamActive Ingredients
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Glycolic Acid
Glycolic Acid
AHA exfoliantThe smallest and most penetrating alpha hydroxy acid for exfoliation and renewal.Benefits
Effective exfoliation
Brightening and radiance
Smoother textureSafe during pregnancy: Safe Safe for sensitive skin: Gradual☀ May increase sun sensitivity
Gradual build-up use
Cautions
Increases sun sensitivity; sunscreen is essential. Introduce gradually on sensitive skin.View ingredient details -
Kojic Acid
Kojic Acid
BrighteningA fungus-derived brightener that inhibits melanin production and treats dark spots.Benefits
Brightens dark spots
Even skin toneSafe during pregnancy: Safe Safe for sensitive skin: GradualDaily use
Cautions
May irritate sensitive skin; introduce gradually on delicate areas.View ingredient details -
Vitamin C
Ascorbic Acid
Antioxidant & brighteningA powerful antioxidant that brightens, evens tone, and protects against environmental damage.Benefits
Brightening and radiance
Even skin tone
Antioxidant protectionSafe during pregnancy: Safe Safe for sensitive skin: GradualMorning (AM) only
Cautions
High concentrations (L-Ascorbic) may irritate sensitive skin; best used in the morning with sunscreen.View ingredient details
Full Ingredient List
Cyclopentasiloxane, Water (Aqua), Propylene Glycol, Glycolic Acid, Cyclodextrin, Ascorbyl Tetraisopalmitate, Sodium Chloride, Divinyldimethicone/Dimethicone Copolymer, Dimethicone Crosspolymer, Kojic Acid, Phenoxyethanol, PEG/PPG-18/18 Dimethicone, Methylparaben, Sodium Metabisulfite, Sodium Sulfate, C12-13 Pareth-23, C12-13 Pareth-3, Fragrance (Parfum), Butylparaben, Ethylparaben
Product Description
Description:
Stubborn hyperpigmentation requires a stronger formula than a regular moisturizer, along with patience and daily sun protection. Unitone 4 Advanced from Isis Pharma targets the appearance of uneven spots: a concentrated evening treatment that helps unify skin tone with regular use, provided that sunscreen is used every morning without exception.
The formula combines glycolic acid with kojic acid and a fatty vitamin C derivative to support a clearer skin appearance. If your skin is sensitive, start with alternate nights and monitor for redness or stinging, reducing frequency if needed. Do not forgo daytime protection throughout the period of use.
How to use:
- In the evening, on clean skin, apply a thin layer to areas of hyperpigmentation or to the entire face if tolerated.
- Start with alternate nights, then gradually increase frequency as comfort allows.
- In the morning, use SPF50+ sunscreen without interruption.
Customer reviews
5 / 5 (1)



























































